Distribution of segmental chromosomal alterations in neuroblastoma.

Victoria CastelP GargalloC FerriolV SeguraY YáñezB JuanA J CañadaJ Font de MoraA CañeteV Castel

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2020)

SCA are not randomly distributed and are concentrated on recurrent chromosomes. The most frequently affected chromosomes identify prognostic factors in specific risk groups. SCA are associated with older age and MNA. We have identified a small subset of patients with better outcome that share whole-chromosome 19 numeric gain, suggesting its use as a prognostic biomarker in NB.

Keyphrases

prognostic factors
copy number
physical activity
community dwelling
middle aged
gene expression
neural network
dna methylation
genome wide
breast cancer risk