Automatic Quantification of Anterior Lamina Cribrosa Structures in Optical Coherence Tomography Using a Two-Stage CNN Framework.

In this study, we propose a new intelligent system to automatically quantify the morphological parameters of the lamina cribrosa (LC) of the optical coherence tomography (OCT), including depth, curve depth, and curve index from OCT images. The proposed system consisted of a two-stage deep learning (DL) model, which was composed of the detection and the segmentation models as well as a quantification process with a post-processing scheme. The models were used to solve the class imbalance problem and obtain Bruch's membrane opening (BMO) as well as anterior LC information. The detection model was implemented by using YOLOv3 to acquire the BMO and LC position information. The Attention U-Net segmentation model is used to compute accurate locations of the BMO and LC curve information. In addition, post-processing is applied using polynomial regression to attain the anterior LC curve boundary information. Finally, the numerical values of morphological parameters are quantified from BMO and LC curve information using an image processing algorithm. The average precision values in the detection performances of BMO and LC information were 99.92% and 99.18%, respectively, which is very accurate. A highly correlated performance of R2 = 0.96 between the predicted and ground-truth values was obtained, which was very close to 1 and satisfied the quantification results. The proposed system was performed accurately by fully automatic quantification of BMO and LC morphological parameters using a DL model.