Effect of food on the pharmacokinetics of the WEE1 inhibitor adavosertib (AZD1775) in patients with advanced solid tumors.

Mats NågårdMei-Lin Ah-SeeKaren SoMarit VermuntFiona ThistlethwaiteMariette LabotsPatricia RoxburghAlain RavaudMario CamponeLiselot Valkenburg-van IerselLone OttesenYan LiGanesh Mugundu

Published in: Cancer chemotherapy and pharmacology (2020)

A high-fat meal did not have a clinically relevant effect on the systemic exposure of adavosertib, suggesting that adavosertib can be administered without regard to meals.

Keyphrases

human health
risk assessment
drug induced