New Insights into IGF-1 Signaling in the Heart.

Published in: Physiology (Bethesda, Md.) (2024)

Insulin-like growth factor-1 (IGF-1) signaling has multiple physiological roles in cellular growth, metabolism, and aging. Myocardial hypertrophy, cell death, senescence, fibrosis, and electrical remodeling are hallmarks of various heart diseases and contribute to the progression of heart failure. This review highlights the critical role of IGF-1 and its cognate receptor in cardiac hypertrophy, aging, and remodeling.

Keyphrases

heart failure
growth hormone
cell death
binding protein
pi k akt
left ventricular
atrial fibrillation
dna damage
signaling pathway
acute heart failure
oxidative stress
cell proliferation
heat stress