Advanced Squamous Cell Carcinomas of the Pelvic and Perineal Region: A Comprehensive Genomic Profiling Study.

Andrea Necchi Philippe E SpiessMarco BandiniGiuseppe BasilePetros GrivasGennady BratslavskyJoseph JacobNatalie DanzigerDouglas LinBrennan DeckerEthan S SokolRichard S P HuangSanjay B KulkarniJeffrey S Ross

Published in: The oncologist (2022)

Despite similar histology, pSCCs can differ in GAs and HPV status. Overall, PIK3CA is the most frequent potentially "targetable" GA followed by mTOR and cell cycle pathway. RTK and DDR GAs are rare in pSCC. Immunotherapy could be considered for pSCC management based on TMB and PD-L1 expression.

Keyphrases

cell cycle
squamous cell
cell proliferation
high grade
room temperature
pet ct
rectal cancer
single cell
copy number
gene expression
protein kinase
ionic liquid