Optimal control of combination immunotherapy for a virtual murine cohort in a glioblastoma-immune dynamics model.
Hannah G AndersonGregory P TakacsJeffrey K HarrisonLibin RongTracy L StepienPublished in: bioRxiv : the preprint server for biology (2024)
A mathematical model of glioma-immune dynamics integrates combination immunotherapy.An optimized regimen extends survival in an average virtual mouse by 79 days.Quality of life and survival outcomes were evaluated for a virtual murine cohort.A high death rate of myeloid-derived suppressor cells predicts long-term survival.