Comparison of anchor-based methods for estimating thresholds of meaningful within-patient change using simulated PROMIS PF 20a data under various joint distribution characteristic conditions.

Shanshan Qin Lauren Nelson Nicole Williams Valerie S L Williams Randall Bender Lori D McLeod

Published in: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation (2022)

To establish accurate and precise thresholds, clinical researchers are recommended to prioritize study designs with at least 50% anchor-defined responders and strongly responsive target endpoints with highly reliable scoring calibration and to select optimal anchor-based methods given the data characteristics.

Keyphrases

electronic health record
big data
case report
high resolution
low cost
clinical evaluation