Metformin and statin use associate with plasma protein N-glycosylation in people with type 2 diabetes.

Sunny S SinghAnnemieke NaberViktoria DotzEmma SchoepElham MemarianRoderick C SliekerPetra J M EldersGerda VreekerSimone NicolardiManfred WuhrerEric J G SijbrandsAloysius G LieverseLeendert M 't Hart Mandy van Hoek

Published in: BMJ open diabetes research & care (2021)

We conclude that metformin and statins associate with a total plasma N-glycome signature in type 2 diabetes. Further studies are needed to determine the causality of these relations, and future N-glycomic research should consider medication a potential confounder.

Keyphrases

type diabetes
cardiovascular disease
adverse drug
healthcare
coronary artery disease
emergency department
risk assessment
protein protein
metabolic syndrome
human health
case control
small molecule