Detection of EGFR Activating and Resistance Mutations by Droplet Digital PCR in Sputum of EGFR-Mutated NSCLC Patients.
Klaus HacknerAnna BuderMaximilian J HochmairMatthaeus StriederChristina GrechHannah FabikanOtto C BurghuberPeter ErrhaltMartin FilipitsPublished in: Clinical Medicine Insights. Oncology (2021)
We demonstrated that EGFR mutation analysis with ddPCR is feasible in sputum samples. Combination of plasma and sputum analyses for detection of T790M in NSCLC patients with progressive disease increases the diagnostic yield compared with molecular plasma analysis alone.
Keyphrases
- small cell lung cancer
- cystic fibrosis
- epidermal growth factor receptor
- mycobacterium tuberculosis
- tyrosine kinase
- pulmonary tuberculosis
- end stage renal disease
- advanced non small cell lung cancer
- chronic kidney disease
- newly diagnosed
- ejection fraction
- brain metastases
- signaling pathway
- loop mediated isothermal amplification
- peritoneal dialysis
- high throughput
- label free
- single cell
- patient reported outcomes