Development of lung metastases in mouse models of tongue squamous cell carcinoma.

Sabrina MarcazzanAli DadbinGiulia BrachiElvin BlancoElena Maria Varoni Giovanni LodiMauro Ferrari

Published in: Oral diseases (2020)

Lung metastases were successfully reproduced by orthotopic and tail vein injection. Since lymph node metastases were present, the orthotopic model with HSC-3 GFP/luciferase cells may be suitable to investigate metastatic dissemination in OSCC.

Keyphrases

squamous cell carcinoma
lymph node
induced apoptosis
mouse model
small cell lung cancer
cell cycle arrest
neoadjuvant chemotherapy
lymph node metastasis
ultrasound guided
locally advanced
cell proliferation
early stage