β -Lactam Pharmacokinetic/Pharmacodynamic Target Attainment in Intensive Care Unit Patients: A Prospective, Observational, Cohort Study.

Romain GuilhaumouConstance ChevrierJean Loup SettiElisabeth Jouve Amélie MarsotNathan JulianOlivier BlinPierre SimeoneDavid LagierDjamel MokartNicolas BruderMarc GarnierLionel Velly

Published in: Antibiotics (Basel, Switzerland) (2023)

-lactam therapy in ICU patients. A large inter- and intra-patient variability in plasmatic concentrations was observed, leading to inadequate exposure. A combined indexed creatinine clearance and TDM approach enables adequate dosing for better pharmacokinetic/pharmacodynamic target attainment.

Keyphrases

intensive care unit
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
peritoneal dialysis
prognostic factors
metabolic syndrome
case report
mechanical ventilation
bone marrow
cell therapy
replacement therapy