Epigenetic silencing of SALL3 is an independent predictor of poor survival in head and neck cancer.

Kiyoshi MisawaDaiki MochizukiAtsushi ImaiYuki MisawaShiori EndoMasato MimaHideya KawasakiThomas E CareyTakeharu Kanazawa

Published in: Clinical epigenetics (2017)

This study suggests that CpG hypermethylation is a likely mechanism of SALL3 gene inactivation, supporting the hypothesis that the SALL3 gene may play a role in the tumorigenesis of HNSCC and may serve as an important biomarker.

Keyphrases

dna methylation
genome wide
copy number
genome wide identification
gene expression
transcription factor