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Antibodies to Malondialdehyde-Acetaldehyde Adduct Are Associated With Prevalent and Incident Rheumatoid Arthritis-Associated Interstitial Lung Disease in US Veterans.

Nozima AripovaGeoffrey M ThieleMichael J DuryeeCarlos D HunterYangyuna YangPunyasha RoulDana P AschermanScott M MatsonGary KunkelGrant W CannonKatherine D WyshamGail S KerrPaul A MonachJoshua F BakerJill A PooleTed R MikulsBryant R England
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
Protein-specific anti-MAA antibodies to collagen, fibrinogen, and vimentin were associated with prevalent RA-ILD. IgA and IgM anti-MAA-albumin antibodies were associated with a higher risk of incident RA-ILD. These findings suggest that MAA modifications and resultant immune responses may contribute to RA-ILD pathogenesis.
Keyphrases
  • interstitial lung disease
  • rheumatoid arthritis
  • systemic sclerosis
  • disease activity
  • idiopathic pulmonary fibrosis
  • immune response
  • cardiovascular disease
  • ankylosing spondylitis
  • type diabetes