Association of the Common Catalase Gene Polymorphism rs1001179 With Glycated Hemoglobin and Plasma Lipids in Hyperlipidemic Patients.
Antonis GoulasDimitrios AgapakisAthanassios ApostolidisDimitra GoudaSotirios AnastassiadisChristina TrakatelliChristos SavopoulosApostolos I HatzitoliosPublished in: Biochemical genetics (2016)
Catalase represents perhaps the most effective antioxidant defense in the body under conditions of increased oxidative stress, and rs1001179 (CAT-262C >T) is its most extensively studied gene polymorphism. Using an established PCR-RFLP method for genotyping, we examined the association of rs1001179 with glycated hemoglobin (HbA1c) and plasma lipids using univariate analyses with age, sex, body mass index (BMI), smoking, and alcohol abuse as covariates, in a group of dyslipidemic patients from northern Greece. Our results suggest that the TT genotype is a risk factor for increased HbA1c and plasma triglycerides, and that this association is modulated by the BMI and/or age of the patients.
Keyphrases
- end stage renal disease
- body mass index
- oxidative stress
- newly diagnosed
- ejection fraction
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- gene expression
- patient reported outcomes
- weight gain
- signaling pathway
- multidrug resistant
- high throughput
- heat stress
- induced apoptosis
- anti inflammatory
- endoplasmic reticulum stress
- intimate partner violence