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TNFR1-mediated senescence and lack of TNFR2-signaling limit human intervertebral disc cell repair in back pain conditions.

Jennifer GansauElena GrossiLevon RodriguezMinghui WangDamien M LaudierSaad B ChaudharyAndrew C HechtWenyu FuRobert P SebraChuanju LiuJames C Iatridis
Published in: bioRxiv : the preprint server for biology (2024)
TNFR1 signaling drives cells towards senesce and muted inflammatory response in painful intervertebral disc degeneration, while limited TNFR2 signaling may limit disc cell repair responses.
Keyphrases
  • inflammatory response
  • endothelial cells
  • single cell
  • cell therapy
  • induced apoptosis
  • dna damage
  • stem cells
  • lipopolysaccharide induced
  • cell cycle arrest
  • immune response
  • cell death
  • stress induced