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Development of caspase-3-selective activity-based probes for PET imaging of apoptosis.

Louis LauwerysLucas BeroskeAngelo SolaniaChristel VangestelAlan MirandaNele Van GielKaruna AdhikariAnne-Marie LambeirLeonie WyffelsDennis WolanPieter Van der VekenFilipe Elvas
Published in: EJNMMI radiopharmacy and chemistry (2024)
F]MICA-316, showed an increase uptake in an in vitro apoptosis model and was able to selectively bind caspase-3 in apoptotic tumour cells. In order to distinguish therapy-responsive from non-responsive tumours, the next generation of caspase-3-selective ABPs will be developed with higher tumour accumulation and in vivo stability.
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