Development of caspase-3-selective activity-based probes for PET imaging of apoptosis.
Louis LauwerysLucas BeroskeAngelo SolaniaChristel VangestelAlan MirandaNele Van GielKaruna AdhikariAnne-Marie LambeirLeonie WyffelsDennis WolanPieter Van der VekenFilipe ElvasPublished in: EJNMMI radiopharmacy and chemistry (2024)
F]MICA-316, showed an increase uptake in an in vitro apoptosis model and was able to selectively bind caspase-3 in apoptotic tumour cells. In order to distinguish therapy-responsive from non-responsive tumours, the next generation of caspase-3-selective ABPs will be developed with higher tumour accumulation and in vivo stability.
Keyphrases
- cell death
- cell cycle arrest
- induced apoptosis
- pet imaging
- endoplasmic reticulum stress
- oxidative stress
- cancer therapy
- small molecule
- signaling pathway
- living cells
- drug delivery
- fluorescence imaging
- cell proliferation
- photodynamic therapy
- mesenchymal stem cells
- computed tomography
- pet ct
- bone marrow
- smoking cessation
- replacement therapy