CXCR6 by increasing retention of memory CD8 + T cells in the ovarian tumor microenvironment promotes immunosurveillance and control of ovarian cancer.

Ravikumar MuthuswamyAj Robert McGraySebastiano BattagliaWenjun HeAnthony MiliottoCheryl EppolitoJunko MatsuzakiTsuji TakemasaRichard KoyaThinle ChodonBrian D LichtyProtul ShrikantKunle Odunsi

Published in: Journal for immunotherapy of cancer (2022)

CXCR6, by promoting retention in tumor tissues, serves a critical role in resident memory T cell-mediated immunosurveillance and control of ovarian cancer. Future studies warrant exploiting CXCR6 to promote resident memory responses in cancers.

Keyphrases

working memory
cell migration
patient safety
quality improvement
gene expression
young adults
case control