Epigenetic regulation of ID4 in breast cancer: tumor suppressor or oncogene?

Daniela NasifEmanuel CampoySergio LauritoRichard BranhamGuillermo UrrutiaMaría RoquéMaría Teresita Branham

Published in: Clinical epigenetics (2018)

We propose that ID4 is frequently silenced by promoter methylation in ER+ breast cancers and functions as a tumor suppressor gene in these tumors, probably due to its interaction with key genes of the ER pathway. Our present study contributes to the knowledge of the role of ID4 in breast cancer.

Keyphrases

genome wide
dna methylation
genome wide identification
estrogen receptor
endoplasmic reticulum
healthcare
breast cancer cells
gene expression
transcription factor
copy number
childhood cancer
young adults