Apigenin alleviates TGF-β1-induced nasal mucosa remodeling by inhibiting MAPK / NF-kB signaling pathways in chronic rhinosinusitis.

Hyun-Woo YangHwee-Jin KimJoo-Hoo Park Jae-Min Shin Heung-Man Lee

Published in: PloS one (2018)

These results suggests the possible use of apigenin as a chronic rhinosinusitis therapeutic agent which can suppress tissue remodeling in nasal mucosa.

Keyphrases

chronic rhinosinusitis
signaling pathway
pi k akt
epithelial mesenchymal transition
induced apoptosis
high glucose
diabetic rats
transforming growth factor
oxidative stress
drug induced
mouse model