Intradiscal Injection of Induced Pluripotent Stem Cell-Derived Nucleus Pulposus-Like Cell-Seeded Polymeric Microspheres Promotes Rat Disc Regeneration.

Kaishun XiaJian ZhuJianming HuaZhe GongChao YuXiaopeng ZhouJingkai WangXianpeng HuangWei YuLiming LiJianqing GaoQixin ChenFangcai LiChengzhen Liang

Published in: Stem cells international (2019)

The results suggest that NP-lC-seeded GDF-5-loaded GMs could partially regenerate degenerated intervertebral discs after transplantation into rat coccygeal intervertebral discs. Our study will help develop a promising method of stem cell-based therapy for IDD.

Keyphrases

stem cells
drug delivery
cell therapy
oxidative stress
cancer therapy
single cell
diabetic rats
high glucose
wound healing
mass spectrometry
drug release
endothelial cells
high resolution