Presence and short-term persistence of SARS-CoV-2 neutralizing antibodies in COVID-19 convalescent plasma donors.

Kyle AnnenThomas E MorrisonMelkon G DomBourianMary K McCarthyLeah HueyPatricia A MerkelGillian AndersenEileen SchwartzVijaya Knight

Published in: Transfusion (2021)

The correlation of neutralizing activity and antigen-binding assays is necessary to qualify CCP for therapeutic use. Since SARS-CoV-2 antibody levels decline in a percentage of donors, and such a decline is not detectable by current qualitative assays implemented in many laboratories, robust, quantitative assays are necessary to evaluate CCP units best suited for therapeutic infusion in COVID-19 patients.

Keyphrases

sars cov
high throughput
respiratory syndrome coronavirus
dengue virus
kidney transplantation
low dose
systematic review
high resolution
mass spectrometry
binding protein