Focused ultrasound-induced blood-brain barrier opening improves adult hippocampal neurogenesis and cognitive function in a cholinergic degeneration dementia rat model.

Jaewoo ShinChanho KongJihyeon LeeBo Young ChoiJiyeon SimChin Su KohMinkyung ParkYoung Cheol NaSang Won SuhWon Seok ChangJin Woo Chang

Published in: Alzheimer's research & therapy (2019)

FUS treatment increased AHN and improved spatial memory. This improvement was mediated by increased hippocampal BDNF and EGR1. FUS treatment may also restore AHN and protect against neurodegeneration, providing a potentially powerful therapeutic strategy for AD.

Keyphrases

blood brain barrier
cerebral ischemia
mild cognitive impairment
oxidative stress
working memory
drug induced