The Immunosuppressive Niche of Soft-Tissue Sarcomas is Sustained by Tumor-Associated Macrophages and Characterized by Intratumoral Tertiary Lymphoid Structures.
Lingling ChenTeniola OkeNicholas SiegelGady CojocaruAda J TamRichard L BlosserJessica SwailesJohn A LigonAndriana LebidCarol D MorrisAdam S LevinDaniel S RheeFabian M JohnstonJonathan B GreerChristian F MeyerBrian H LadleElizabeth D ThompsonElizabeth A MontgomeryWoonyoung ChoiDavid J McConkeyRobert A AndersDrew M PardollNicolas J LlosaPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Our work in STS revealed an immunosuppressive TME dominated by myeloid cells, which may be overcome with activation of T cells that traffic into the tumor. In rhabdomyosarcomas, targeting T cells found within TLS may be key to achieve antitumor response.