m6 A facilitates YTHDF-independent phase separation.

Si-Yu LiuYi FengJun-Jie WuMing-Li ZouZi-Li SunXia LiFeng-Lai Yuan

Published in: Journal of cellular and molecular medicine (2019)

N6-methyladenosine (m6 A) is one of the most abundant messenger RNA (mRNA) modifications in eukaryotes and is involved in various key processes of RNA metabolism. In this issue of Nature, Ries et al (2019) described the fundamental features of m6A modification of mRNAs in regulating the composition of the phase-separated transcriptome on the basis of number and distribution, and provide strong evidence that m6A plays a role in regulating phase separation in cells.

Keyphrases

induced apoptosis
cell cycle arrest
gene expression
nucleic acid
single cell
genome wide
endoplasmic reticulum stress
oxidative stress
binding protein
cell proliferation
cell death
pi k akt
genome wide analysis