Divergent Associations of Slow-Wave Sleep versus Rapid Eye Movement Sleep with Plasma Amyloid-Beta.

Yevgenia RosenblumMariana PereiraOliver StangeFrederik D WeberLeonore BovySofia TzioridouElisa LanciniDavid A NevilleNadja KleinTimo de WolffMandy StritzkeIris KerstenManfred UhrJurgen A H R ClaassenAxel SteigerMarcel M Verbeek Martin Dresler

Published in: Annals of neurology (2024)

Slow-wave oscillations are associated with higher plasma amyloid-beta levels, whereas REM sleep is related to decreased amyloid-beta plasma levels, possibly representing changes in central amyloid-beta production or clearance. Strong associations between cortisol, growth hormone, and amyloid-beta presumably reflect the sleep-regulating role of the corresponding releasing hormones. A positive association between age and amyloid-beta-40 may indicate that peripheral clearance becomes less efficient with age. ANN NEUROL 2024;96:46-60.

Keyphrases

physical activity
sleep quality
working memory
depressive symptoms
quantum dots
sensitive detection