Decreased pancreatic acinar cell number in type 1 diabetes.

Jordan J Wright Diane C SaundersChunhua DaiGreg PoffenbergerBrynn CairnsDavid V SerrezeDavid M Harlan Rita Bottino Marcela Brissova Simeon I Taylor

Published in: Diabetologia (2020)

Pancreases from donors with type 1 diabetes are smaller than normal donor pancreases because exocrine cells are fewer in number rather than smaller in size; these changes occur early in the disease process. Our mouse data suggest that decreased pancreas size in type 1 diabetes is not directly caused by insulin deficiency, but the precise mechanism responsible remains unclear.

Keyphrases

type diabetes
glycemic control
induced apoptosis
single cell
cardiovascular disease
cell cycle arrest
insulin resistance
cell therapy
big data
electronic health record
cell death
oxidative stress
mesenchymal stem cells
machine learning
bone marrow
weight loss
skeletal muscle
data analysis