Bifidobacterium longum SX-1326 ameliorates gastrointestinal toxicity after irinotecan chemotherapy via modulating the P53 signaling pathway and brain-gut axis.
Fenfang YueXiangdi ZengYufan WangYilin FangMengyun YueXuanqi ZhaoRuizhe ZhuQingwei ZengJing WeiTingtao ChenPublished in: BMC microbiology (2024)
In conclusion, our work reveals that B. longum SX-1326 has a favorable effect in adjuvant irinotecan for CRC and amelioration of post-chemotherapy side effects, and also provides the theoretical basis and data for finding a safe and efficient chemotherapeutic adjuvant.
Keyphrases
- signaling pathway
- early stage
- locally advanced
- pi k akt
- resting state
- electronic health record
- epithelial mesenchymal transition
- oxidative stress
- big data
- mouse model
- squamous cell carcinoma
- rectal cancer
- radiation therapy
- multiple sclerosis
- cerebral ischemia
- functional connectivity
- machine learning
- blood brain barrier
- data analysis
- endoplasmic reticulum stress