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PD-1 and PD-L1 expression on T-cell subsets in women with unexplained recurrent pregnancy losses.

Wen-Juan WangMaria Dinorah Salazar GarciaGloria DeutschNayoung SungXiuhua YangQiaohua HeGiovanni JubizMahmood BilalSvetlana DambaevaAlice Gilman-SachsKenneth D BeamanJoanne Kwak-Kim
Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2020)
PD-1 and PD-L1 expressions on Th17 cells as well as PD-1 expression on Th1 cells were significantly downregulated in women with RPL, which may lead to increased Th1 and Th17 immunity, and imbalance between Th17, Th1, and Treg cells in women with RPL.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • endoplasmic reticulum stress
  • oxidative stress
  • cell death
  • pregnant women
  • preterm birth
  • peripheral blood
  • binding protein
  • pregnancy outcomes