HPV-associated cervical cancer cells targeted by triblock copolymer gold nanoparticle curcumin combination.

J Chen-SandovalC C PerryJ YunP J Chan

Published in: European journal of gynaecological oncology (2018)

Curcumin increased HeLa cancer cell necrosis but its cytotoxicity was decreased by copolymer GNPs. The results suggested that this specific copolymer GNP did not enhance the curcumnin bioavailability in cultured cells possibly due to formation of copolymer GNP aggregates.

Keyphrases

induced apoptosis
cell cycle arrest
drug release
endoplasmic reticulum stress
endothelial cells
signaling pathway
cancer therapy