Genetic Predictors for Fecal Propionate and Butyrate-Producing Microbiome Pathway Are Not Associated with Colorectal Cancer Risk: A Mendelian Randomization Analysis.

Yujia Lu Yu Chen Zhao Jenny Chang-Claude Stephen B Gruber Andrea Gsur Kenneth Offit Ludmila Vodickova Michael O Woods Long H Nguyen Kaitlin H Wade Robert Carreras-Torres Victor Moreno Daniel D Buchanan Michelle Cotterchio Andrew T Chan Amanda I Phipps Ulrike Peters Mingyang Song

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2023)

Fecal propionate and PWY-5022 may not have a substantial influence on colorectal cancer risk. Future research is warranted to comprehensively investigate the effects of SCFA-producing bacteria and SCFAs on colorectal cancer risk.

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