Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression.

María Juárez-Fernández Naroa Goikoetxea-Usandizaga David Porras María Victoria García-Mediavilla Miren Bravo Marina Serrano-Maciá Jorge Simon Teresa Cardoso Delgado Sofia Lachiondo-Ortega Susana Martínez-Flórez Óscar LorenzoMercedes RincónMarta Varela-ReyLeticia Abecia Héctor Rodríguez Juan Anguita Esther Nistal María Luz Martínez-Chantar Sonia Sánchez-Campos

Published in: Hepatology (Baltimore, Md.) (2022)

Overall, we provide evidence for the relevance of mitochondria-microbiota interplay during NASH and that targeting it could be a valuable therapeutic approach.

Keyphrases

oxidative stress
cell death
cancer therapy
reactive oxygen species
endoplasmic reticulum