Controllable growth of Au nanostructures onto MoS2 nanosheets for dual-modal imaging and photothermal-radiation combined therapy.
Teng LiuSida ShenYing HuangXiao ZhangZhuangchai LaiThu Ha TranZhuang LiuLiang ChengPublished in: Nanoscale (2019)
Multifunctional theranostic nanoagents are attractive to realize comprehensive imaging and effective treatment of tumours. Herein, a novel strategy is developed to controllably guide the epitaxial growth of gold nanostructures onto MoS2 nanosheets. The as-prepared MoS2-Au nanostructures (MA) manifest an enhanced near-infrared (NIR) absorbance with strong photostability. After modification, the obtained MA-PEG shows strong X-ray attenuation and photothermal conversion ability, promising for CT and photoacoustic imaging with an enhanced intensity in tumours. Moreover, in vivo photothermal and radiation therapy with MA-PEG achieves synergistic tumour treatment efficiency through hyperthermia elevated oxygenation level and sensitized radiation therapy. This work illustrates the development of a unique MA nanostructure with enhanced NIR absorbance and strong photoelectric absorbance as a multifunctional theranostic agent with great potential for dual-modal imaging-guided photothermal-radiation therapy of cancer.
Keyphrases
- photodynamic therapy
- radiation therapy
- drug delivery
- cancer therapy
- high resolution
- fluorescence imaging
- reduced graphene oxide
- drug release
- quantum dots
- sensitive detection
- radiation induced
- squamous cell carcinoma
- highly efficient
- mass spectrometry
- computed tomography
- room temperature
- gold nanoparticles
- magnetic resonance imaging
- transition metal
- fluorescent probe
- positron emission tomography
- contrast enhanced
- bone marrow