Inverse correlation between age of onset and myocardial amyloid deposition quantified by 99m Tc-PYP scintigraphy in patients with wild-type transthyretin amyloid cardiomyopathy.

Hiroshi KanayaShinya ShiraishiKouji OgasawaraKoya IwashitaFumi SakamotoSeiji TakashioYoshiki MikamiKenichi TsujitaToshinori Hirai

Published in: Annals of nuclear medicine (2024)

The H/CL ratio, Hb, and Cr independently affect age of onset in patients with ATTRwt-CM. The H/CL ratio is inversely correlated with age of onset, and may be the sole factor in the development of heart failure in early onset patients, while it may have a synergistic effect on heart failure with anemia and renal dysfunction in late-onset patients.

Keyphrases

early onset
late onset
heart failure
end stage renal disease
chronic kidney disease
newly diagnosed
ejection fraction
wild type
left ventricular
prognostic factors
oxidative stress
atrial fibrillation