A simulation study of cell size and volume fraction mapping for tissue with two underlying cell populations using diffusion-weighted MRI.

This proof-of-concept study proposed a diffusion MRI-based method for voxel-wise estimation of cell radii and volume fractions of two cell populations when they coexist in the same MR voxel. The ability to reliably characterize tissue with two cell populations opens exciting avenues of potential applications in both tumor diagnosis and treatment monitoring.