tRNA-derived small RNA, 5'tiRNA-Gly-CCC, promotes skeletal muscle regeneration through the inflammatory response.

Linyuan ShenTianci LiaoQiuyang ChenYuhang LeiLinghui WangHao GuYanhao QiuTing ZhengYiting YangChenggang WeiLei ChenYe ZhaoLili NiuShunhua ZhangYan ZhuMingzhou LiJinyong WangXuewei LiMailin GanLi Zhu

Published in: Journal of cachexia, sarcopenia and muscle (2023)

These results reveal that 5'tiRNA-Gly potentially regulated skeletal muscle regeneration by inducing inflammation via the TGF-β signalling pathway. The findings of this study uncover a new potential target for skeletal muscle regeneration treatment.

Keyphrases

skeletal muscle
stem cells
inflammatory response
insulin resistance
wound healing
oxidative stress
lipopolysaccharide induced
type diabetes
single cell
gene expression
adipose tissue
combination therapy
epithelial mesenchymal transition
nucleic acid