Downregulation of fibromodulin attenuates inflammatory signaling and atrial fibrosis in spontaneously hypertensive rats with atrial fibrillation via inhibiting TLR4/NLRP3 signaling pathway.
Yuming LiangYun ZhouJialin WangYan HePublished in: Immunity, inflammation and disease (2023)
Downregulation of FMOD attenuated inflammatory signaling and atrial fibrosis in SHR-AF by inhibiting the TLR4/NLRP3 signaling pathway. Therefore, FMOD may be a promising therapeutic target in AF.
Keyphrases
- signaling pathway
- atrial fibrillation
- catheter ablation
- left atrial
- pi k akt
- oral anticoagulants
- toll like receptor
- induced apoptosis
- left atrial appendage
- epithelial mesenchymal transition
- direct oral anticoagulants
- inflammatory response
- immune response
- oxidative stress
- heart failure
- percutaneous coronary intervention
- nlrp inflammasome
- acute coronary syndrome
- venous thromboembolism
- mitral valve