Effects of Memantine on the Spontaneous Firing Frequency of Hippocampal CA1 Pyramidal Neurons in Intact and Alzheimer Rat Model: An Electrophysiological Study.
Nastaran ZamaniAhmad Ali MoazediMohammad Reza AfarineshMehdi Pourmehdi BoroujeniPublished in: Basic and clinical neuroscience (2022)
Results showed that memantine increases the electrical activity of CA1 pyramidal neurons in a rat model of AD. Furthermore, in the intact adult male rats, the low-dose memantine, contrary to high dose, does not decrease the electrical activity of CA1 pyramidal neurons.