Acquired immunological imbalance after surgery with cardiopulmonary bypass due to epigenetic over-activation of PU.1/M-CSF.

Krzysztof LaudanskiMateusz ZawadkaJacek PolosakJaymin ModiMatthew DiMeglioJacob GutscheWilson Y SzetoMonika Puzianowska-Kuznicka

Published in: Journal of translational medicine (2018)

We concluded that at 3 months after cardiopulmonary bypass, monocytes continued to express a new macrophage-like milieu that was associated with the persistent activation of the PU.1/M-CSF pathway.

Keyphrases

dna methylation
gene expression
adipose tissue
cerebrospinal fluid
immune response