Prospective Evaluation of the Addition of Polygenic Risk Scores to Breast Cancer Risk Models.
Sherly X LiJonathan BeesleyTu Nguyen-DumontXiaochuan WangDallas R EnglishGraham G GilesMelissa C SoutheyAntonis C AntoniouAndrew J LeeSherly X LiIngrid WinshipJohn L HopperMary Beth TerryRobert J MacInnisPublished in: JNCI cancer spectrum (2021)
Although the inclusion of a 313 genetic variant PRS doubles discriminatory accuracy (relative to reference 0.50), models with and without this PRS have relatively modest discrimination and might require recalibration before their clinical and wider use are promoted.
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