Mutational landscape and predictors of survival in head and neck mucosal melanoma.

Brandon M LehrichArash AbiriTheodore V NguyenBenjamin F BitnerCharles C L TongEdward Cheng-Lung Kuan

Published in: International forum of allergy & rhinology (2023)

Head and neck mucosal melanomas have a diverse mutational landscape with low mutational burden. A molecular subset (∼13%) has ROS1 mutations, which is an actionable driver mutation. ROS1-mutated patients have improved overall survival likely due to high mutational burden.

Keyphrases

end stage renal disease
cell death
ejection fraction
newly diagnosed
chronic kidney disease
reactive oxygen species
prognostic factors
risk factors
ulcerative colitis
free survival
single molecule
patient reported