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Methods for improving the immunogenicity and efficacy of cancer vaccines.

Lorenzo PillaSoldano FerroneCristina Maccalli
Published in: Expert opinion on biological therapy (2018)
Additional and appropriate preclinical studies are warranted to optimize the immunogenicity and delivery of cancer vaccines. The appropriate choice of target antigens is challenging; however, the exploitation of neoantigens generated from somatic mutations of tumor cells represents a promising approach to target highly immunogenic tumor-specific antigens. Remarkably, the investigation of the combination of cancer vaccines with immunomodulating agents able to skew the tumor microenvironment from immunosuppressive to immunostimulating will dramatically improve their clinical efficacy.
Keyphrases
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