Genomic analysis to screen potential genes and mutations in children with non-syndromic early onset severe obesity: a multicentre study in Turkey.
Aysehan AkinciAltan KaraAykut ÖzgürDoga TurkkahramanSoner AksuPublished in: Molecular biology reports (2021)
We propose that 12 of non-synonymous pathogenic variations detected on ADIPOQ, ADRB2, PPARGC1A, UCP1, and IRS1 genes might have a cumulative effect on the development and progression of obesity.
Keyphrases
- early onset
- insulin resistance
- late onset
- metabolic syndrome
- weight loss
- high fat diet induced
- genome wide
- type diabetes
- weight gain
- bioinformatics analysis
- genome wide identification
- young adults
- high throughput
- genome wide analysis
- intellectual disability
- adipose tissue
- gene expression
- human health
- climate change
- physical activity