MPTP-induced dopaminergic neurotoxicity in mouse brain is attenuated after subsequent intranasal administration of (R)-ketamine: a role of TrkB signaling.

Atsuhiro FujitaYuko FujitaYaoyu PuLijia ChangKenji Hashimoto

Published in: Psychopharmacology (2019)

These findings suggest that (R)-ketamine can protect against MPTP-induced neurotoxicity in the mouse brain via TrkB activation. Therefore, (R)-ketamine could represent a therapeutic drug for neurodegenerative disorders such as PD.

Keyphrases

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