Assessment of the Zoonotic Potential of Atypical Scrapie Prions in Humanized Mice Reveals Rare Phenotypic Convergence but Not Identity With Sporadic Creutzfeldt-Jakob Disease Prions.

Alba Marín-MorenoFabienne ReineLaetitia HerzogNaima AronFlorence JaffrézicJean-Luc VilotteHuman RezaeiOlivier AndréolettiDavy MartinVincent Beringue

Published in: The Journal of infectious diseases (2024)

The results obtained suggest a low zoonotic potential for AS. Rare adaptation may allow the emergence of prions phenotypically resembling those spontaneously forming in humans.

Keyphrases

late onset
human health
high fat diet induced
metabolic syndrome
monoclonal antibody
insulin resistance
early onset
wild type