BNT162b2 vaccine-induced humoral and cellular responses against SARS-CoV-2 variants in systemic lupus erythematosus.

Quentin MoyonDelphine SterlinMakoto MiyaraFrançois AnnaAlexis MathianRaphael LhotePascale Ghillani-DalbinPaul BreillatSasi MudumbaSophia de AlbaFleur Cohen-AubartJulien HarocheMicheline PhaThi Huong Du BoutinHedi ChaiebPedro Macedo FloresPierre CharneauGuy GorochovZahir Amoura

Published in: Annals of the rheumatic diseases (2021)

MMF, MTX and poor baseline humoral immune status, particularly low naïve B cell frequencies, are independently associated with impaired BNT162b2 mRNA antibody response, delineating patients with SLE who might need adapted vaccine regimens and follow-up.

Keyphrases

sars cov
immune response
systemic lupus erythematosus
high glucose
diabetic rats
copy number
respiratory syndrome coronavirus
disease activity
drug induced
oxidative stress
endothelial cells
binding protein