Next-Generation Immunosequencing Reveals Pathological T-Cell Architecture in Autoimmune Hepatitis.

Christoph SchultheißDonjete SimnicaEdith WillscherAnna OberleLorenzo FanchiNicola BonzanniNils H WildnerJulian Schulze Zur WieschChristina Weiler-NormannAnsgar W LohseMascha Binder

Published in: Hepatology (Baltimore, Md.) (2021)

Patients with AIH show profound and persisting T-cell architectural changes that may explain high relapse rates after tapering immunosuppression. Liver T-cell clusters shared between patients may mediate liver damage and warrant further study.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
oxidative stress
multiple sclerosis
intellectual disability
patient reported outcomes