Netrin G1 Ligand is a new stromal immunomodulator that promotes pancreatic cancer.
Debora Barbosa Vendramini-CostaRalph FrancesconeJanusz Franco-BarrazaTiffany LuongMyree GravesAriana Musa de AquinoNina SteeleJaye C GardinerSérgio Alexandre Alcantara Dos SantosCharline OgierEmily MalloyLeila BorghaeiEsteban MartinezDmitry I ZhigarevYinfei TanHayan LeeYan ZhouKathy Q CaiAndres J Klein-SzantoHuamin WangMark AndrakeRoland L DunbrackKerry CampbellEdna CukiermanPublished in: bioRxiv : the preprint server for biology (2024)
Here we uncovered the pro-tumor roles of the synaptic protein NGL-1 in the tumor microenvironment of pancreatic cancer, defining a new target that simultaneously modulates tumor cell, fibroblast, and immune cell functions. This study reports a new pathway where NGL-1 controls TGF-β, AP-1 transcription factor members and NFAT1, modulating the immunosuppressive microenvironment in pancreatic cancer. Our findings highlight NGL-1 as a new stromal immunomodulator in pancreatic cancer.