The effect of reduced glutathione on the toxicity of silver diamine fluoride in rat pulpal cells.

Seunggun KimMohannad NassarYukihiko TamuraNoriko HiraishiAhmed JamlehToru NikaidoJunji Tagami

Published in: Journal of applied oral science : revista FOB (2021)

SDF severely disturbed the viability, mineralization-ability, and morphology of pulpal-like cells, while controlled concentrations of GSH had a short-term protective effect against SDF-induced damage. GSH showed an inhibitory effect on SDF-induced dentinal deposit formation. Further research is warranted to evaluate the effect of GSH on caries-arresting, anti-hypersensitivity, and antibacterial functions of SDF.

Keyphrases

oxidative stress
diabetic rats
high glucose
drug induced
fluorescent probe
induced apoptosis
silver nanoparticles
cell cycle arrest
signaling pathway
endoplasmic reticulum stress
stress induced
wound healing