Association of first trimester prescription opioid use with congenital malformations in the offspring: population based cohort study.
Brian T BatemanSonia Hernandez-DiazLoreen StraubYanmin ZhuKathryn J GrayRishi J DesaiHelen MogunNileesa GautamKrista F HuybrechtsPublished in: BMJ (Clinical research ed.) (2021)
Prescription opioids used in early pregnancy are not associated with a substantial increase in risk for most of the malformation types considered, although a small increase in the risk of oral clefts associated with their use is possible.