Bacterial lysate add-on therapy to reduce exacerbations in severe asthma: A double-blind placebo-controlled trial.
Geertje Maria de BoerGerrit J BraunstahlEsmee K van der PloegCathelijne M van ZelstAlie van BruggenGuido EppingMenno van NimwegenGert VerhoevenErwin BirnieBianca M Boxma-de KlerkMarjolein J W de BruijnRalph StadhoudersRudi W HendriksGerdien A Tramper-StandersPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)
Although OM-85 may have immune-modulatory effects, it did not reduce asthma exacerbations in this heterogeneous severe adult asthma group. Post hoc analysis showed a potential clinical benefit in patients with type 2 inflammation.